An interoperable and secure architecture for internet-scale decentralized personal communication

Interpersonal network communications, including Voice over IP (VoIP) and Instant Messaging (IM), are increasingly popular communications tools. However, systems to date have generally adopted a client-server model, requiring complex centralized infrastructure, or have not adhered to any VoIP or IM standard. Many deployment scenarios either require no central equipment, or due to unique properties of the deployment, are limited or rendered unattractive by central servers. to address these scenarios, we present a solution based on the Session Initiation Protocol (SIP) standard, utilizing a decentralized Peer-to-Peer (P2P) mechanism to distribute data. Our new approach, P2PSIP, enables users to communicate with minimal or no centralized servers, while providing secure, real-time, authenticated communications comparable in security and performance to centralized solutions.;We present two complete protocol descriptions and system designs. The first, the SOSIMPLE/dSIP protocol, is a P2P-over-SIP solution, utilizing SIP both for the transport of P2P messages and personal communications, yielding an interoperable, single-stack solution for P2P communications. The RELOAD protocol is a binary P2P protocol, designed for use in a SIP-using-P2P architecture where an existing SIP application is modified to use an additional, binary RELOAD stack to distribute user information without need for a central server.;To meet the unique security needs of a fully decentralized communications system, we propose an enrollment-time certificate authority model that provides asserted identity and strong P2P and user-level security. In this model, a centralized server is contacted only at enrollment time. No run-time connections to the servers are required.;Additionally, we show that traditional P2P message routing mechanisms are inappropriate for P2PSIP. The existing mechanisms are generally optimized for file sharing and neglect critical practical elements of the open Internet --- namely link-level security and asymmetric connectivity caused by Network Address Translators (NATs). In response to these shortcomings, we introduce a new message routing paradigm, Adaptive Routing (AR), and using both analytical models and simulation show that AR significantly improves message routing performance for P2PSIP systems.;Our work has led to the creation of a new research topic within the P2P and interpersonal communications communities, P2PSIP. Our seminal publications have provided the impetus for subsequent P2PSIP publications, for the listing of P2PSIP as a topic in conference calls for papers, and for the formation of a new working group in the Internet Engineering Task Force (IETF), directed to develop an open Internet standard for P2PSIP

Oral fluorography: Detection of corneal vascularization

Corneal vascularization is a pathological process occurring in a cornea suffering physical and/or physiological insult. Its presentation could impair clear vision and thus its detection is important. Unfortunately current methods to detect and grade corneal vascularization are largely subjective and therefore a uniform system to identify and grade its presence does not exist. This study has explored a method using oral fluorescein angiography to examine corneal vessel growth. The results show that corneal vascularization fluoresces and leaks fluorescein during an oral fluorescein study. This information indicates that a method potentially exists to detect, grade and follow corneal vascularization through an objective means

Assessing Self-Repair on FPGAs with Biologically Realistic Astrocyte-Neuron Networks

This paper presents a hardware based implementation of a biologically-faithful astrocyte-based selfrepairing mechanism for Spiking Neural Networks. Spiking Astrocyte-neuron Networks (SANNs) are a new computing paradigm which capture the key mechanisms of how the human brain performs repairs. Using SANN in hardware affords the potential for realizing computing architecture that can self-repair. This paper demonstrates that Spiking Astrocyte Neural Network (SANN) in hardware have a resilience to significant levels of faults. The key novelty of the paper resides in implementing an SANN on FPGAs using fixed-point representation and demonstrating graceful performance degradation to different levels of injected faults via its self-repair capability. A fixed-point implementation of astrocyte, neurons and tripartite synapses are presented and compared against previous hardware floating-point and Matlab software implementations of SANN. All results are obtained from the SANN FPGA implementation and show how the reduced fixedpoint representation can maintain the biologically-realistic repair capability

Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation

In this review, we discuss how changes in the intragraft microenvironment serve to promote or sustain the development of chronic allograft rejection. We propose two key elements within the microenvironment that contribute to the rejection process. The first is endothelial cell proliferation and angiogenesis that serve to create abnormal microvascular blood flow patterns as well as local tissue hypoxia, and precedes endothelial-to-mesenchymal transition. The second is the overexpression of local cytokines and growth factors that serve to sustain inflammation and, in turn, function to promote a leukocyte-induced angiogenesis reaction. Central to both events is overexpression of vascular endothelial growth factor (VEGF), which is both pro-inflammatory and pro-angiogenic, and thus drives progression of the chronic rejection microenvironment. In our discussion, we focus on how inflammation results in angiogenesis and how leukocyte-induced angiogenesis is pathological. We also discuss how VEGF is a master control factor that fosters the development of the chronic rejection microenvironment. Overall, this review provides insight into the intragraft microenvironment as an important paradigm for future direction in the field

SKITTER/implement mechanical interface

SKITTER (Spacial Kinematic Inertial Translatory Tripod Extremity Robot) is a three-legged transport vehicle designed to perform under the unique environment of the moon. The objective of this project was to design a mechanical interface for SKITTER. This mechanical latching interface will allow SKITTER to use a series of implements such as drills, cranes, etc., and perform different tasks on the moon. The design emphasized versatility and detachability; that is, the interface design is the same for all implements, and connection and detachment is simple. After consideration of many alternatives, a system of three identical latches at each of the three interface points was chosen. The latching mechanism satisfies the design constraints because it facilitates connection and detachment. Also, the moving parts are protected from the dusty environment by housing plates

Lunar crane hook

The base and ball hook system is an attachment that is designed to be used on the lunar surface as an improved alternative to the common crane hook and eye system. The design proposed uses an omni-directional ball hook and base to overcome the design problems associated with a conventional crane hook. The base and ball hook is not sensitive to cable twist which would render a robotic lunar crane useless since there is little atmospheric resistance to dampen the motion of an oscillating member. The symmetric characteristics of the ball hook and base eliminates manual placement of the ball hook into the base; commonly associated with the typical hook and eye stem. The major advantage of the base and ball hook system is it's ease of couple and uncouple modes that are advantages during unmanned robotic lunar missions